WE SOLVE HARD PROBLEMS
We provide specialized bioinformatic services to advance your technological and scientific goals
Tim Fennell is a Founding Partner at Fulcrum Genomics LLC, with over a decade of experience in genomics and bioinformatics. He combines a background in computer science and large-scale software engineering with a passion for molecular biology, genetics, and statistics in order to rapidly solve challenging problems in genomics. Prior to founding Fulcrum Genomics, Tim served as Director of Bioinformatics at the Broad Institute where he led the development and operation of pipelines for the institute's Next Generation Sequencing (NGS) data, the bioinformatics strategy for the creation of a CLIA licensed clinical sequencing lab, and was the lead author of the industry standard Picard suite of programs for working with NGS data. Before moving into the life sciences, Tim was a business and technology consultant at Sapient Corporation where he developed innovative process and technological solutions to solve business challenges for clients in the Energy Services, Financial Services and Healthcare industries.
Nils Homer is a Founding Partner at Fulcrum Genomics LLC and has over a decade of cutting-edge experience developing methods and software for the analysis of next-generation sequencing data. He has led high-pace technology and product development efforts at both industry and academic positions, and has directed teams of software developers to support the largest academic genome sequencing facility in the world for both research and clinical applications. Nils has also participated in the technology development and subsequent commercial launch of multiple sequencing assays and technologies, providing critical understanding for technical improvements in chemistry, molecular biology, and software. He combines his skill in developing novel methods, algorithms, and software with his understanding of the data produced to provide key insights into biological research and discovery. Nils holds a Masters and PhD in Computer Science from UCLA investigating methods applied to genomics, including alignment and variant detection for whole genome sequencing. He received his BA (Computer Science and Mathematics) from Colgate University. Nils previously served on the Scientific Advisory Board for Edico Genome until acquisition by Illumina.
Principal Bioinformatics Software Engineer
Jay Carey has over two decades of experience in software engineering and bioinformatics. Combining a love for technology and science, he has provided practical and pragmatic solutions for the technical challenges of processing large genomic data sets. He has led teams of engineers to tackle the multitude of complex issues involved in scaling the processing of genomic data, while preserving the scientific validity of the data being produced. Prior to joining Fulcrum Genomics, Jay was the Technical Lead and Principal Software Engineer for the NGS Production Pipelines team at the Broad Institute. He led the team responsible for expanding the Broad Institute's production sequencing pipelines by utilizing cloud processing and also wrote and maintained the pipeline and LIMS for all genotyping arrays. In addition, he was a maintaining author of both the Picard suite of tools and the HTSJDK file formats specifications. In his freetime, Jay enjoys spending time with his family and skiing.
Principal Bioinformatics Engineer
Seth Stadick has over half a decade of experience working with high throughput next-generation sequencing pipelines and platforms. As a software engineer and biologist, he has a diversified background in the bioinformatics field and has led projects ranging from algorithm development to large scale cloud infrastructure deployments. He has experience working within both small, fast-paced start-ups, and large enterprises. In both environments, he has been a key asset in the successful releases of commercial products. Seth holds a MS in Bioinformatics and a BS in Molecular and Cellular Biology from Johns Hopkins University.
Nathan Roach has almost a decade of experience working closely with biologists to solve computational problems and over half a decade of experience working in bioinformatics specifically. Nathan received his PhD in Biology from the Cell, Molecular, Developmental Biology and Biophysics department at Johns Hopkins University for his thesis work on the computational analysis of long-read direct-RNA-sequencing. He also has a dual degree B.S. in Biology and Computer Science from the University of North Carolina at Chapel Hill. He's leveraged his training in both Biology and Computer Science to facilitate development of novel analysis tools and pipelines, both in industry and academia.
Principal Bioinformatics Engineer
Pam has over a decade of computational genomics and bioinformatics experience in academic and industry settings. She combines a passion for scientific innovation with a strong grounding in rigorous analytic and engineering practices. In her career as a computational biologist at the Broad Institute, Caltech, and the University of Colorado, Pam built computational solutions for novel problems in molecular biology, comparative genomics, human genetics, and radiogenomics. She also conceived and led the first ever large-scale study of bioinformatics code and software development practices. Prior to joining Fulcrum, Pam worked as a computational scientist at Inscripta Inc., delivering production software engineering and bioinformatic solutions to support the development of a groundbreaking high-throughput digital genome engineering platform. Pam holds a BA and and an MA in mathematics from the University of Pennsylvania and an MA in applied mathematics from the University of California-San Diego. In her free time, Pam enjoys spending time with her family, hiking, and performing improv comedy.
Founded in August of 2015, Fulcrum Genomics LLC provides specialized bioinformatic services to advance technology and the understanding of human disease. Utilizing our extensive experience in both industry and academia, and in research and clinical settings, we adapt tools and pipelines to suit your needs. We have extensive experience from designing assays for target capture, including solution-based as well as multiplex PCR. We have participated in developing novel sequencing technologies and assays, from signal processing through primary analysis and finally interpretation, while providing critical insight into upstream improvements in laboratory preparation. We have built and operated analysis pipelines to support the most high-through genomic production environments, managing the analysis and storage of petabytes of data, along with critical laboratory and phenotypic metadata, both in research and CLIA licensed environments. We strive to understand your problems and provide solutions that you can use to improve your research and product development or for your technology and assay.
Let us help you focus on your strengths by providing our vision, strategy, and experience in bioinformatics and genomics.